Here, a highly distinguished team of authors from top institutes around the world leads . An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. Gallbladder cancer (GBC) is a highly lethal disease and is the most common cancer of the biliary tract. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic . It is also one of the most studied topics among cell biologists. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy: New Perspectives and Opportunities is written by Author and published by Springer. Abstract Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. In this apoptosis-positive group, the positive rate of expression of the p53 protein (21.4%, 3 out of 14) was lower as compared to findings in the apoptosis-negative group (66.7%, 10 out of 15). The compound strongly suppressed AKT expression in the peritoneal nodules. Clin Cancer Res 2003, 9: 2826-2836. Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, tumour metastasis and resistance to anticancer drugs. Fas/Fas ligand (FasL) system is one of the key apoptotic signaling entities in the extrinsic apoptotic pathway. Apoptosis in cancer: from pathogenesis to treatment Rebecca SY Wong Abstract Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions.. Apoptosis was first described by Kerr and colleagues in 1972 [ 17] as a physiological situation characterized by distinguishable morphological features such as nuclear changes (nuclear chromatin condensation and nuclear fragmentation), cell contraction, and losing attachment with adjacent cells. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. . apoptosis was first described as a pathological feature of pkd by woo in 1995 ( 49 ), in that apoptotic dna fragmentation and nuclei were detected in cystic renal cells and tissues from human adpkd and arpkd, the congenital polycystic kidney (cpk) mouse model of arpkd, and the pcy mouse model that is orthologous to adolescent nephronophthisis ( Apoptosis in cancer: from pathogenesis to treatment. Cancer is the utmost common disease-causing death worldwide, characterized by uncontrollable cell division with the potential of metastasis. It is also one of the most studied topics among cell biologists. Apoptosis in cancer: from pathogenesis to treatment @article{Wong2011ApoptosisIC, title={Apoptosis in cancer: from pathogenesis to treatment}, author={Rebecca SY Wong}, journal={Journal of Experimental \& Clinical Cancer Research : CR}, year={2011}, volume={30}, pages={87 - 87} } R. S. Wong; Published 26 September 2011; Medicine, Biology It is also one of the most studied topics among cell biologists. Spontaneous apoptosis was evident in the pre-treatment cancer tissues of 14 patients (48.2%). Apoptosis in cancer: from pathogenesis to treatment Rebecca SY Wong Abstract Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and patholog ical conditions.. J. . An in-depth understanding of lncRNAs will provide new targets for cancer treatment and improve clinical treatment of the disease. Cancer is a complex disease including approximately 200 different entities that can potentially affect all body tissues. It is also one of the most studied topics among cell biologists. Rebecca Wong. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. De-regulation of this pathway, i.e. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies,. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most studied topics among cell biologists. Overexpression of the Inhibitors of Apoptosis proteins (IAPs) and autophagy correlates with tumorigenesis, therapeutic resistance, and reoccurrence after anticancer therapies. Save up to 80% versus print by going digital with VitalSource. Apoptosis in the Pathogenesis and Treatment of Disease Craig B. Thompson Science 10 Mar 1995 Vol 267, Issue 5203 pp. . In addition, the compound induced higher levels of apoptosis in pancreatic cancer cell lines than did -bisabolol. Journal of experimental & clinical cancer research, 30(1), 1-14. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. It is usually diagnosed at a late stage with poor prognosis, often as an incidental finding . Among the conventional treatments, radiotherapy and chemotherapy are most often applied to different types of cancers. Death and anti-death: tumour . Apoptosis is one of the most-studied programmed cell death mechanisms, let ABclonal help you further characterize the apoptotic factors and pathways! Igney, F. H., & Krammer, P. H. (2002). Download Apoptosis And Cancer Therapy books, Since most cancer therapies primarily act by inducing apoptosis in tumor cells, insights into the molecular mechanisms regulating apoptosis are crucial to developing novel, more effective treatment strategies. The mechanism of apoptosis is complex and involves many pathways. -Bisabolol derivative 5 inhibited xenograft tumor growth and reduced dissemination of pancreatic cancer to peritoneal nodules. It is also one of the most studied topics among cell biologists. by mutations may prevent the immune system from the removal of newly-formed tumor cells, and thus lead to tumor formation. An understanding of the underlying mechanism of apoptosis is important as it plays a pivotal role in the pathogenesis of many diseases. Recent evidence suggests that alterations in cell survival contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome). Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. The Digital and eTextbook ISBNs for Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy are 9783319394060, 3319394061 and the print ISBNs are 9783319394046, 3319394045. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. Despite substantial advances in the development of innovative antineoplastic drugs, cancer remains one of the most significant causes of death, worldwide . Abstract Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. In some, the problem is due to too much apoptosis, such as in the case of . Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy: New Perspectives and Opportunities (Advances in Experimental Medicine and Biology, 930): 9783319818801: Medicine & Health Science Books @ Amazon.com 1456 - 1462 DOI: 10.1126/science.7878464 0 0 Abstract References e Letters (0) Current Issue Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice By Muna Al-Habsi et al. R. S. Apoptosis in cancer: from pathogenesis to treatment. It is also one of the most studied topics among cell biologists. This study illuminates the role and efficacy of smac mimetic compound BV6 alone . Hu Y, Cherton-Horvat G, Dragowska V, Baird S, Korneluk RG, Durkin JP, Mayer LD, LaCasse EC: Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo. PDF - Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions. It is also one of the most Apoptosis in cancer: from pathogenesis to treatment | springermedizin.de Dehydroclatidine can induce cell cycle arrest in the G2/M phase, activate the apoptosis pathway mediated by mitochondria and death receptors, reduce the viability of liver cancer cells, and trigger apoptosis of liver cancer cells by inhibiting JNK1/2 phosphorylation (Velmurugan et al., 2022).
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